Redox-based endoplasmic reticulum dysfunction in neurological diseases
نویسندگان
چکیده
منابع مشابه
Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise
Pathological endoplasmic reticulum (ER) stress is tightly linked to the accumulation of reactive oxidants, which can be both upstream and downstream of ER stress. Accordingly, detrimental intracellular stress signals are amplified through establishment of a vicious cycle. An increasing number of human diseases are characterized by tissue atrophy in response to ER stress and oxidative injury. Ex...
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Probably the most important message that a Forum on the reduction–oxidation (redox) environment in the endoplasmic reticulum (ER) must nowadays convey is that an ‘‘ER redox state’’ as such does not exist. The ER rather features a variety of redox systems, which—in many cases—react independently with incoming substrates and xenobiotics. Thus, any statement claiming ER hyperor hypo-oxidation unde...
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The endoplasmic reticulum (ER) serves several important functions, mainly post-translational modification, folding and assembly of newly synthesized secretary proteins, synthesizing lipids and cellular calcium storage. Various factors can disrupt ER homeostasis and disturb its functions, which leads to the accumulation of unfolded and misfolded proteins and to potential cellular dysfunction and...
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Living cells must be able to respond to physiological and environmental fluctuations that threaten cell function and viability. A cellular event prone to disruption by a wide variety of internal and external perturbations is protein folding. To ensure protein folding can proceed under a range of conditions, the cell has evolved transcriptional, translational, and posttranslational signaling pat...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2008
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.2008.05571.x